1,1-Dimethylbiguanide Hydrochloride, MP Biomedicals™

Description

1,1-Dimethylbiguanide Hydrochloride, White Powder

• It has various medical uses such as in polycystic ovary syndrome, non-alcoholic fatty liver disease and diabetes mellitus type 2.
• It may also reduce weight gain in people taking atypical antipsychotics. 1,1-Dimethylbiguanide hydrochloride is suitable biguanide agent used in a study to investigate its role in enhancing the secretions of plasma active glucagon-like peptide-1 (GLP-1) levels.
• 1,1-Dimethylbiguanide, Hydrochloride (Metformin) is a biguanide antihyperglycemic agent. 1,1-Dimethylbiguanide hydrochloride (metformin) is a strong base.
• It forms well defined salts and possessing excellent coordination capacity with transition metals, forming highly colored bidentate chelate complexes.
• Metformin (MET) exists in various forms: diprotonated (H2MET)2+ in strong acidic solution, monoprotonated (HMET)+ in weak acid, MET in neutral and deprotonated (MET)- in strong alkali solution. It is an oral antidiabetic drug.
• Pharmacokinetics of metformin has been studied. Determination of metformin in human plasma has been described by simple HPLC-UV method.[5] Metformin is reported to increase plasma active glucagon-like peptide-1 (GLP-1) in humans

Specifications

• CAS: 1115-70-4
• Melting Point: 214°C to 224°C
• Color: White
• Molecular Formula: C4H12ClN5
• MDL Number: MFCD00012582
• Quantity: 25 g
• Synonym: metformin hydrochloride, 1,1-dimethylbiguanide hydrochloride, metformin hcl, glucophage, riomet, diabefagos, meguan, metformin monohydrochloride, benofomin, denkaform
• Solubility Information: Soluble in water (100mg/mL - clear, colorless solution), 95% ethanol; insoluble in ether, acetone or chloroform.
• InChI Key: OETHQSJEHLVLGH-UHFFFAOYSA-N
• SMILES: [H+].[Cl-].CN(C)C(=N)N=C(N)N
• IUPAC Name: 3-(diaminomethylidene)-1,1-dimethylguanidine;hydrochloride
• Molecular Weight (g/mol): 165.63
• PubChem CID: 14219
• Formula Weight: 165.6
• Physical Form: Powder
• Chemical Name or Material: 1, 1-Dimethylbiguanide Hydrochloride

Safety and Handling

Product Identifier

• 1,1-Dimethylbiguanide Hydrochloride

Signal Word

• Warning

Hazard Category

• Acute toxicity Category 4
• Serious eye damage/eye irritation Category 2
• Skin corrosion/irritation Category 2

Hazard Statement

• H302-Harmful if swallowed.
• H315-Causes skin irritation.
• H319-Causes serious eye irritation.

Precautionary Statement

• P264-Wash thoroughly after handling.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
• P303+P361+P353-IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P321-Specific treatment (see on this label).
• P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.

Supplemental information

• MIXTURE LIST-Contains : Metformin Hydrochloride