1-(2-Aminoethyl)piperidine, 98%, Thermo Scientific Chemicals

Product Code	Brand	Quantity
11448297	Thermo Scientific Alfa Aesar A18373.06	5 g
11458297	Thermo Scientific Alfa Aesar A18373.14	25 g

Description

1-(2-Aminoethyl)piperidine is used in modification of vinylbenzyl chloride/divinylbenzene gel copolymer bead and in the synthesis of linkage isomers trans-bis[1-(2-aminoethyl)piperidine]dinitronickel and trans-bis[1-(2-aminoethyl)-piperidine]dinitritonickel. It is also used as a reactant for synthesis of: analogs of anticancer agents, inhibitor of botulinum neurotoxin serotype A light chain, P. falciparum malaria, and Ebola filovirus, cannabinoid CB1 receptor antagonists, small molecules that restore E-cadherin expression and reduce invasion in colorectal carcinoma cells, potent and selective 5-HT6 antagonists and N-mustards as anticancer agents. 1-(2-Aminoethyl)piperidine on [1+1] condensation reaction with 3-methoxy salicylaldehyde yields tridentate Schiff base ligand.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
1-(2-Aminoethyl)piperidine is used in modification of vinylbenzyl chloride/divinylbenzene gel copolymer bead and in the synthesis of linkage isomers trans-bis[1-(2-aminoethyl)piperidine]dinitronickel and trans-bis[1-(2-aminoethyl)-piperidine]dinitritonickel. It is also used as a reactant for synthesis of: analogs of anticancer agents, inhibitor of botulinum neurotoxin serotype A light chain, P. falciparum malaria, and Ebola filovirus, cannabinoid CB1 receptor antagonists, small molecules that restore E-cadherin expression and reduce invasion in colorectal carcinoma cells, potent and selective 5-HT6 antagonists and N-mustards as anticancer agents. 1-(2-Aminoethyl)piperidine on [1+1] condensation reaction with 3-methoxy salicylaldehyde yields tridentate Schiff base ligand.

Solubility
Partly miscible in water.

Notes
Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents, acid chlorides and acid anhydrides. It is sensitive to air.

Chemical Identifiers

• CAS: 27578-60-5
• Molecular Weight (g/mol): 128.219
• InChI Key: CJNRGSHEMCMUOE-UHFFFAOYSA-N
• PubChem CID: 33944
• SMILES: C1CCN(CC1)CCN

• Molecular Formula: C7H16N2
• MDL Number: MFCD00006516
• Synonym: n-2-aminoethyl piperidine, 1-2-aminoethyl piperidine, 2-piperidin-1-yl ethanamine, 2-piperidin-1-yl ethan-1-amine, 1-piperidineethanamine, 2-piperidinoethylamine, 2-1-piperidinyl ethanamine, 2-1-piperidinyl ethylamine, n-aminoethylpiperidine, 2-piperidino-1-ethanamine
• IUPAC Name: 2-piperidin-1-ylethanamine

Specifications

• CAS: 27578-60-5
• Boiling Point: 185°C to 186°C
• Molecular Formula: C7H16N2
• MDL Number: MFCD00006516
• Beilstein: 103469
• Synonym: n-2-aminoethyl piperidine, 1-2-aminoethyl piperidine, 2-piperidin-1-yl ethanamine, 2-piperidin-1-yl ethan-1-amine, 1-piperidineethanamine, 2-piperidinoethylamine, 2-1-piperidinyl ethanamine, 2-1-piperidinyl ethylamine, n-aminoethylpiperidine, 2-piperidino-1-ethanamine
• InChI Key: CJNRGSHEMCMUOE-UHFFFAOYSA-N
• IUPAC Name: 2-piperidin-1-ylethanamine
• PubChem CID: 33944
• Percent Purity: 98%

• Density: 0.903
• Flash Point: 57°C (134°F)
• Refractive Index: 1.474
• UN Number: UN2733
• Sensitivity: Air Sensitive
• Solubility Information: Partly miscible in water.
• SMILES: C1CCN(CC1)CCN
• Molecular Weight (g/mol): 128.219
• Formula Weight: 128.22
• Chemical Name or Material: 1-(2-Aminoethyl)piperidine

Safety and Handling

GHS H Statement
H314-H318-H226
Causes severe skin burns and eye damage.
Causes serious eye damage.
Flammable liquid and vapour.

P210-P233-P240-P241-P242-P243-P260-P264b-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P370+P378q-P501c

H226-H314

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missing translation for 'tsca' : No

Recommended Storage : Ambient temperatures

Signal Word

• Danger

Hazard Category

• Serious eye damage/eye irritation Category 1
• Flammable liquid Category 3
• Skin corrosion/irritation Category 1 B

Hazard Statement

• H226-Flammable liquid and vapour.
• H314-Causes severe skin burns and eye damage.
• H318-Causes serious eye damage.

Precautionary Statement

• P210-Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P303+P361+P353-IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P310-Immediately call a POISON CENTER/doctor/.

RUO – Research Use Only