1,4-Dithio-DL-threitol, 98%, Thermo Scientific Chemicals

Description

Useful for stabilizing sulfhydryl-containing enzymes1,4-Dithio-DL-threitol is used as a protective agent in preventing oxidation of thiol groups and reagent for the reduction of disulfide groups in proteins. It is employed to investigate a-ketoglutarate dehydrogenase function, flavin cofactors in proteins and protein moieties involved in peroxide reduction. It is also useful for stabilizing sulfhydryl-containing enzymes.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Useful for stabilizing sulfhydryl-containing enzymes1,4-Dithio-DL-threitol is used as a protective agent in preventing oxidation of thiol groups and reagent for the reduction of disulfide groups in proteins. It is employed to investigate a-ketoglutarate dehydrogenase function, flavin cofactors in proteins and protein moieties involved in peroxide reduction. It is also useful for stabilizing sulfhydryl-containing enzymes.

Solubility
Soluble in water, ethanol, chloroform, diethyl ether, acetone, ether and ethyl acetate.

Notes
Air sensitive and hygroscopic. Store in a cool place. Incompatible with strong oxidizing agents, reducing agents and alkalies.

Specifications

Chemical Identifiers

• CAS: 3483-12-3
• Molecular Formula: C4H10O2S2
• Molecular Weight (g/mol): 154.24
• MDL Number: MFCD00004877
• InChI Key: VHJLVAABSRFDPM-IMJSIDKUSA-N
• Synonym: dithiothreitol, dl-1,4-dithiothreitol, dl-dithiothreitol, 1,4-dithio-dl-threitol, d-1,4-dithiothreitol, d-dtt, 2s,3s-1,4-dimercaptobutane-2,3-diol, threo-1,4-dimercapto-2,3-butanediol, 1,4-dithiothreitol, dtt
• PubChem CID: 446094
• ChEBI: CHEBI:42170
• IUPAC Name: (2S,3S)-1,4-bis(sulfanyl)butane-2,3-diol
• SMILES: C(C(C(CS)O)O)S

• Melting Point: 40°C to 43°C
• Boiling Point: 125°C to 130°C (12 mmHg)
• Flash Point: >110°C (230°F)
• Odor: Unpleasant
• Quantity: 25 g
• Beilstein: 1719757
• Sensitivity: Air sensitive
• Merck Index: 14,3376
• Solubility Information: Soluble in water,ethanol,chloroform,diethyl ether,acetone,ether and ethyl acetate.
• Formula Weight: 154.25
• Percent Purity: 98%
• Chemical Name or Material: 1,4-Dithio-DL-threitol

Safety and Handling

Product Identifier

• 1,4-Dithio-DL-threitol

Signal Word

• Warning

Hazard Category

• Acute toxicity Category 4
• Serious eye damage/eye irritation Category 2
• Skin corrosion/irritation Category 2
• Specific target organ toxicity Category 3

Hazard Statement

• H302-Harmful if swallowed.
• H315-Causes skin irritation.
• H319-Causes serious eye irritation.
• H335-May cause respiratory irritation.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P312-Call a POISON CENTER/doctor/if you feel unwell.
• P332+P313-If skin irritation occurs: Get medical advice/attention.
• P337+P313-If eye irritation persists: Get medical advice/attention.

Supplemental information

• MIXTURE LIST-Contains : 1,4-Dithio-DL-threitol

RUO – Research Use Only