ML 221, Tocris Bioscience™

Description

Apelin antagonist

Apelin receptor (APJ) antagonist (IC50 values are 0.70 and 1.75 μM in a cAMP assay and β-arrestin assay, respectively). Displays >37-fold selectivity over the closely related angiotensin II type 1 (AT1) receptor. Exhibits no toxicity towards human hepatocytes at concentrations >50 μM.

Specifications

Chemical Identifiers

• CAS: 877636-42-5
• Molecular Formula: C17H11N3O6S
• Molecular Weight (g/mol): 385.35
• InChI Key: UASIRTUMPRQVFY-UHFFFAOYSA-N
• Synonym: 4-oxo-6-pyrimidin-2-ylsulfanylmethyl pyran-3-yl 4-nitrobenzoate, 4-oxo-6-pyrimidin-2-ylthio methyl-4h-pyran-3-yl 4-nitrobenzoate, d05nxx, 4-oxo-6-pyrimidin-2-ylsulfanyl methyl pyran-3-yl 4-nitrobenzoate, 5-4-nitrobenzoyl oxy-2-2-pyrimidinylthio methyl-4h-pyran-4-one
• PubChem CID: 7217941
• IUPAC Name: [4-oxo-6-(pyrimidin-2-ylsulfanylmethyl)pyran-3-yl] 4-nitrobenzoate
• SMILES: C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)[N+](=O)[O-]

• Quantity: 10 mg
• Formula Weight: 385.35
• Percent Purity: >99%
• Chemical Name or Material: ML 221