2,6-Dichlorobenzoyl chloride, 98%, Thermo Scientific Chemicals

Description

2,6-Dichlorobenzoyl chloride acts as an important intermediate in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs. It is employed in the substrate activity screening method for the rapid development of novel substrates and their conversion into non-peptidic inhibitors of Cys and Ser proteases. It is also used in the preparation of 1-acyliridoles and (-)-aspicilin. In addition to this, it undergoes esterification of (fluoren-9-ylmethoxy)carbonyl (Fmoc)-amino acids to 4-alkoxybenzyl alcohol polystyrene.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
2,6-Dichlorobenzoyl chloride acts as an important intermediate in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs. It is employed in the substrate activity screening method for the rapid development of novel substrates and their conversion into non-peptidic inhibitors of Cys and Ser proteases. It is also used in the preparation of 1-acyliridoles and (-)-aspicilin. In addition to this, it undergoes esterification of (fluoren-9-ylmethoxy)carbonyl (Fmoc)-amino acids to 4-alkoxybenzyl alcohol polystyrene.

Solubility
Miscible with alcohol, ether and acetone. Slightly miscible with heptane. Immiscible with water.

Notes
Moisture sensitive. Incompatible with alcohols, oxidizing agents and strong bases.

Specifications

Chemical Identifiers

• CAS: 4659-45-4
• Molecular Formula: C7H3Cl3O
• Molecular Weight (g/mol): 209.45
• MDL Number: MFCD00000662
• InChI Key: JBLIDPPHFGWTKU-UHFFFAOYSA-N
• Synonym: benzoyl chloride, 2,6-dichloro, 2,6-dichlorobenzoylchloride, unii-394f6s81wy, 2,6-dichloro-benzoyl chloride, ccris 8617, pubchem18674, acmc-209k7i, 2.6-dichlorobenzoylchloride, dsstox_cid_12891, dsstox_rid_79043
• PubChem CID: 78392
• IUPAC Name: 2,6-dichlorobenzoyl chloride
• SMILES: C1=CC(=C(C(=C1)Cl)C(=O)Cl)Cl

• Melting Point: 15°C to 18°C
• Density: 1.463
• Boiling Point: 130°C to 132°C (15 mmHg)
• Flash Point: >110°C (230°F)
• Refractive Index: 1.56
• Quantity: 50 g
• UN Number: UN3265
• Beilstein: 639531
• Sensitivity: Moisture sensitive
• Solubility Information: Miscible with alcohol,ether and acetone. Slightly miscible with heptane. Immiscible with water.
• Formula Weight: 209.46
• Percent Purity: 98%
• Chemical Name or Material: 2,6-Dichlorobenzoyl chloride

Safety and Handling

Signal Word

• Danger

Hazard Category

• LONG-TERM AQUATIC HAZARD Chronic 3
• Serious eye damage/eye irritation Category 1
• Skin corrosion/irritation Category 1 B

Hazard Statement

• H314-Causes severe skin burns and eye damage.
• H318-Causes serious eye damage.
• H412-Harmful to aquatic life with long lasting effects.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P303+P361+P353-IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P310-Immediately call a POISON CENTER/doctor/.

RUO – Research Use Only