2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one, 97%, Thermo Scientific Chemicals

Description

2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one is a reagent used in phosphorylation and phosphitylation of alcohols and in the formation of H-phosphonates. It is also reactive cyclic phosphitylating reagent involved in fast coupling rates and hydrolytic cleavage more readily compare to that of a acyclic analog.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one is a reagent used in phosphorylation and phosphitylation of alcohols and in the formation of H-phosphonates. It is also reactive cyclic phosphitylating reagent involved in fast coupling rates and hydrolytic cleavage more readily compare to that of a acyclic analog.

Solubility
Soluble in acetonitrile, dichloromethane, tetrahydrofuron and dimethylformamide.

Notes
Light and heat sensitive. Incompatible with water and strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 5381-99-7
• Molecular Formula: C7H4ClO3P
• Molecular Weight (g/mol): 202.53
• MDL Number: MFCD00013353
• InChI Key: BVOITXUNGDUXRW-UHFFFAOYNA-N
• Synonym: 2-chloro-4h-1,3,2-benzodioxaphosphorin-4-one, 2-chloro-4h-benzo d 1,3,2 dioxaphosphinin-4-one, van boom's reagent, 2-chloro-4h-1,2,3-benzodioxaphosphorin-4-one, 4h-1,3,2-benzodioxaphosphorin-4-one, 2-chloro, salicylchlorophosphite, salicyl chlorophosphite, acmc-1an3b, 2-chloro-4h-1,3,2-benzodioxaphosphinin-4-one, salicylchlorophosphite; van boom's reagent
• PubChem CID: 237010
• IUPAC Name: 2-chloro-1,3,2-benzodioxaphosphinin-4-one
• SMILES: ClP1OC(=O)C2=CC=CC=C2O1

• Melting Point: 36°C to 40°C
• Boiling Point: 127°C to 128°C (11 mmHg)
• Flash Point: >110°C (230°F)
• Quantity: 5 g
• UN Number: UN3261
• Sensitivity: Moisture sensitive
• Solubility Information: Soluble in acetonitrile,dichloromethane,tetrahydrofuron and dimethylformamide.
• Formula Weight: 202.54
• Percent Purity: 97%
• Chemical Name or Material: 2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one

Safety and Handling

Product Identifier

• 2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one

Signal Word

• Danger

Hazard Category

• Serious eye damage/eye irritation Category 1
• Skin corrosion/irritation Category 1 B

Hazard Statement

• H314-Causes severe skin burns and eye damage.
• H318-Causes serious eye damage.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P303+P361+P353-IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P310-Immediately call a POISON CENTER/doctor/.

Supplemental information

• MIXTURE LIST-Contains : 2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one

RUO – Research Use Only