Thermo Scientific Chemicals 2'-Deoxyguanosine monohydrate, 98+%

Description

Deoxyguanosine (dG) is a purine nucleoside that upon sequential phosphoylation (kinases) forms dGTP which is used by DNA polymerases and reverse transcriptases to synthesis DNA(s). Deoxyguanosine is the most electron rich of the four canonical bases and includes many nucleophilic sites which are susceptible to oxidative damage. This makes deoxyguanosine and its oxidized derivatives useful reagents to study mechanisms of oxidative damage to nucleosides and nucleotides.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Deoxyguanosine (dG) is a purine nucleoside that upon sequential phosphoylation (kinases) forms dGTP which is used by DNA polymerases and reverse transcriptases to synthesis DNA(s). Deoxyguanosine is the most electron rich of the four canonical bases and includes many nucleophilic sites which are susceptible to oxidative damage. This makes deoxyguanosine and its oxidized derivatives useful reagents to study mechanisms of oxidative damage to nucleosides and nucleotides.

Solubility
Soluble in NH4OH 1 M: 50 mg/mL, clear to very faintly turbid.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 961-07-9
• Molecular Formula: C10H13N5O4
• Molecular Weight (g/mol): 267.25
• MDL Number: MFCD00150760
• InChI Key: YKBGVTZYEHREMT-DWFKHXNSNA-N
• Synonym: 2'-deoxyguanosine, deoxyguanosine, guanine deoxyriboside, 2-deoxyguanosine, guanosine, 2'-deoxy, guanine deoxy nucleoside, 2'-deoxy-guanosine, 2;-deoxyguanosine, unii-g9481n71ro, guanine, 9-2-deoxy-beta-d-erythro-pentofuranosyl
• PubChem CID: 187790
• ChEBI: CHEBI:17172
• IUPAC Name: 2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
• SMILES: NC1=NC2=C(N=CN2[C@H]2C[C@H](O)[C@@H](CO)O2)C(=O)N1

• Color: White
• Quantity: 1 g
• Solubility Information: Soluble in NH4OH 1 M: 50mg/mL,clear to very faintly turbid.
• Formula Weight: 285.26 (267.25 Anhydrous)
• Physical Form: Crystalline Powder
• Chemical Name or Material: 2'-Deoxyguanosine

Safety and Handling

Product Identifier

• 2'-Deoxyguanosine monohydrate

Signal Word

• Warning

Hazard Category

• Acute toxicity Category 4

Hazard Statement

• H302-Harmful if swallowed.

Precautionary Statement

• P264-Wash face, hands and anyexposed skin thoroughly after handling.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P312-Call a POISON CENTER/doctor/if you feel unwell.

Supplemental information

• MIXTURE LIST-Contains : 2'-Deoxyguanosine monohydrate

RUO – Research Use Only