Thermo Scientific Chemicals 2'-Deoxyuridine, 98+%, Thermo Scientific Chemicals

Description

2'-Deoxyuridine is frequently halogenated to create thymidine analogues useful for studies of DNA synthesis and degradation mechanisms. Derivatized 2?-Deoxyuridines used as labeling substrates include chloro-2?-deoxyuridine (CldU), bromodeoxyuridine (BrdU) and/or iododeoxyuridine (IdU). Other useful analogues of 2?-deoxyuridine include 5-ethynyl-2?-deoxyuridine (DdU) and 5-hydroxymethyl-2?-deoxyuridine (HmdU). Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemias due to vitamin B12 and folate deficiencies. Deoxyuridine (dU) is used to indirectly determine if there are sufficient levels of folate and cobalamin in cell or tissue samples.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
2′-Deoxyuridine is frequently halogenated to create thymidine analogues useful for studies of DNA synthesis and degradation mechanisms. Derivatized 2′-Deoxyuridines used as labeling substrates include chloro-2′-deoxyuridine (CldU), bromodeoxyuridine (BrdU) and/or iododeoxyuridine (IdU). Other useful analogues of 2′-deoxyuridine include 5-ethynyl-2′-deoxyuridine (DdU) and 5-hydroxymethyl-2′-deoxyuridine (HmdU). Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemias due to vitamin B12 and folate deficiencies. Deoxyuridine (dU) is used to indirectly determine if there are sufficient levels of folate and cobalamin in cell or tissue samples.

Solubility
Soluble in water.

Notes
Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents. It is sensitive to air.

Specifications

Chemical Identifiers

• CAS: 951-78-0
• Molecular Formula: C9H12N2O5
• Molecular Weight (g/mol): 228.20
• MDL Number: MFCD00006527
• InChI Key: MXHRCPNRJAMMIM-SHYZEUOFSA-N
• Synonym: 2'-deoxyuridine, deoxyuridine, uracil deoxyriboside, 2-deoxyuridine, 1-2r,4s,5r-4-hydroxy-5-hydroxymethyl tetrahydrofuran-2-yl pyrimidine-2,4 1h,3h-dione, deoxyribose uracil, uridine, 2'-deoxy, 2'-desoxyuridine, unii-w78i7ay22c, ccris 2832
• PubChem CID: 13712
• ChEBI: CHEBI:16450
• IUPAC Name: 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
• SMILES: OC[C@H]1O[C@H](C[C@@H]1O)N1C=CC(=O)NC1=O

• Melting Point: 164°C to 167°C
• Quantity: 25 g
• Beilstein: 24433
• Sensitivity: Air Sensitive
• Merck Index: 14,2910
• Solubility Information: Soluble in water.
• Optical Rotation: +52° (c=1.1 in 1N NaOH)
• Formula Weight: 228.21
• Percent Purity: 99%
• Chemical Name or Material: 2'-Deoxyuridine

RUO – Research Use Only