Thermo Scientific™ TheraPure™ 2'-Fluoro-U Phosphoramidite, 28-400 finish bottle

2'-Fluoro-U CEP is a phosphoramidite containing 5' DMT and the nucleoside uridine (U) with 2'-Fluoro protection, for use in oligonucleotide synthesis.

Brand:  Thermo Scientific™ 27-1602-12

Product Code. 17927172

Description

2'-Fluoro-U CEP is a phosphoramidite containing 5' DMT and the nucleoside uridine (U) with 2'-Fluoro protection, for use in oligonucleotide synthesis. Located in the ideal oligo position, the highly electronegative fluorine (2'-Fluoro) modification adopts a more thermodynamically stable A-form helix on hybridization to its target. Showing improved affinity and some nuclease resistance (compared to 2'-OH), the 2'-F modification has been proven useful in antisense, siRNA, and aptamer applications. The TheraPure trademark denotes our highest level of phosphoramidite purity, developed with the greatest stringency of high definition analytics and tightly controlled impurity profiles and, therefore, ideal for any therapeutic application. This product is supplied in a 30-mL amber bottle with a 28-400 finish neck style, which is compatible with most MerMade synthesizers.

Features:
• Full chemical name: 5'-O-(4,4'-Dimethoxytrityl)-2'-fluorouridine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular formula: C₃₉H₄₆FN₄O₈P
• Base: A
• Formula weight: 748.8 g/mol
• CAS number: 146954-75-8
• HPLC purity: >98%
• ³¹P NMR purity: ≥98%

Specifications

• For Use With (Equipment): MerMade Synthesizers
• Content And Storage: Store in freezer (at or below -20°C).
• Reagent Features: 2in-Fluoro modified
• Purity: 98%
• Reagent Type: Phosphoramidite
• Nucleic Acid Type: RNA
• Form: Powder

• Product Type: 2in-Fluoro-U CEP
• Nucleoside Type: Uridine (U)
• Shipping Condition: Room Temperature
• Quantity: 0.5 g
• Grade: TheraPure™
• Product Line: TheraPure™

For Research Use Only. Not for use in diagnostic procedures.