Suramin hexasodium salt, 98+%, Thermo Scientific™

Product Code. 15454249

Brand: Thermo Scientific Alfa Aesar J61707.MD

Description

Suramin hexasodium salt (suramin sodium, CAS # 129-46-4) is the sodium salt of suramin.

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

General Description

• Suramin is a polysulphonated napthylurea which exhibits anti-parasitic and anticancer properties

• Suramin prevents endothelial cell migration and proliferation through inhibition of IGF-I, EGF, PDGF, and TGF-beta

• Suramin can also uncouple G-proteins from receptors and turn off cell signaling cascades

Application

• Suramin inhibits angiogenesis through blockade of bFGF and VEGF and can be useful for the laboratory study of blood vessel growth and renewal following injury

• Suramin inhibits DNA topoisomerases, and can be used as an antineoplastic agent in the laboratory study of cancer or for studies of microbial physiology

Specifications

• CAS: 129-46-4
• Molecular Formula: C51H34N6Na6O23S6
• MDL Number: MFCD00210217
• Quantity: 250mg
• Beilstein: 3694087
• Merck Index: 14,9006
• Synonym: suramin sodium, suramin hexasodium, suramin hexasodium salt, suramin sodium salt, antrypol, moranyl, naganinum, naphuride sodium, fourneau 309, suramine sodium salt
• Solubility Information: Soluble in water and saline; Sparingly soluble in 95% bethanol
• InChI Key: VAPNKLKDKUDFHK-UHFFFAOYSA-H
• SMILES: [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].CC1=CC=C(C=C1NC(=O)C1=CC(NC(=O)NC2=CC(=CC=C2)C(=O)NC2=CC(=CC=C2C)C(=O)NC2=C3C(C=C(C=C3S([O-])(=O)=O)S([O-])(=O)=O)=C(C=C2)S([O-])(=O)=O)=CC=C1)C(=O)NC1=C2C(C=C(C=C2S([O-])(=O)=O)S([O-])(=O)=O)=C(C=C1)S([O-])(=O)=O
• IUPAC Name: hexasodium 8-{4-methyl-3-[3-({[3-({2-methyl-5-[(4,6,8-trisulfonatonaphthalen-1-yl)carbamoyl]phenyl}carbamoyl)phenyl]carbamoyl}amino)benzamido]benzamido}naphthalene-1,3,5-trisulfonate
• Molecular Weight (g/mol): 1429.15
• PubChem CID: 8514
• Formula Weight: 1429.16
• Percent Purity: ≥98%
• Chemical Name or Material: Suramin hexasodium salt

Safety and Handling

SDS

RUO – Research Use Only