STEMCELL Technologies 3-Deazaneplanocin A

Epigenetic modifier; Inhibits histone EZH2 lysine methyltransferase

Product Code	Brand	Quantity
17170052	STEMCELL Technologies 72322	500 μg
17180052	STEMCELL Technologies 72324	1 mg

Description

• Deazaneplanocin A (DZNep) is an inhibitor of lysine methyltransferases, particularly EZH2
• DZNep therefore acts as an epigenetic modifier, specifically inhibiting the trimethylation of Histone 3, Lysine 27, by depleting levels of EZH2
• (Miranda et al.), Tan et al.), Tseng et al.)
• Enables chemical reprogramming (without genetic factors) of mouse embryonic fibroblasts to induced pluripotent stem (iPS) cells, in combination with CHIR99021, Forskolin, VaL^proic Acid, Tranylcypromine, and E-616452, by increasing OCT4 expression at later stages of reprogramming (Hou et al.)
• Reactivation of XIST-dependent inactive X chromosomes in human embryonic stem cells (Diaz Perez et al.)
• Inhibits self-renewal of glioblastoma multiforme cancer stem cells (Suva et al.)
• Inhibits survival of acute myeloid leukemia blast cells, in combination with a histone deacetylase inhibitor (Fiskus et al.)

Specifications

• CAS: 102052-95-9
• Synonym: DZNep; NSC 617989
• Molecular Formula: C₁₂H₁₄N₄O₃