3-Isobutyl-1-Methylxanthine, MP Biomedicals™

Description

Known as IBMX. 3-Isobutyl-1-Methylxanthine, MP Biomedicals is a potent, non-specific inhibitor of cAMP and cGMP phosphodiesterases, significantly more effective than theophylline. This inhibition activates PKA, leading to decreased proliferation, increase

A non-specific inhibitor of adenosine 3',5'-cyclic monophosphate phosphodiesterase (cAMP PDE)4, significantly more effective than theophylline. Also inhibits cGMP phosphodiesterases. IBMX inhibits cyclic nucleotide PDE with subsequent inhibition of cyclic nucleotide hydrolysis, resulting in accumulation of cyclic AMP and guanosine 3',5'-cyclic monophosphate.

• Inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3μM)
• Serves as an adenosine receptor antagonist
• Inhibits ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells
• Induces calcium release from intracellular stores in sensory neurons
• Inhibits the growth of carcinoma cells both in vivo and in vitro in mice

Specifications

Chemical Identifiers

• CAS: 28822-58-4
• Molecular Formula: C10H14N4O2
• Molecular Weight (g/mol): 222.25
• MDL Number: MFCD00005584
• InChI Key: APIXJSLKIYYUKG-UHFFFAOYSA-N
• Synonym: 3-isobutyl-1-methylxanthine, ibmx, isobutylmethylxanthine, 1-methyl-3-isobutylxanthine, methylisobutylxanthine, 3-isobutyl-1-methyl-1h-purine-2,6 3h,7h-dione, xanthine, 3-isobutyl-1-methyl, 3-isobutyl-1-methyxanthine, 1h-purine-2,6-dione, 3,7-dihydro-1-methyl-3-2-methylpropyl, methyl-isobutylxanthine
• PubChem CID: 3758
• ChEBI: CHEBI:43253
• IUPAC Name: 1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione
• SMILES: CC(C)CN1C2=C(NC=N2)C(=O)N(C)C1=O

• Melting Point: 195°C to 202°C
• Quantity: 100 mg
• Formula Weight: 222.25
• Physical Form: Powder

Safety and Handling

Signal Word

• Warning

Hazard Category

• Acute toxicity Category 4

Hazard Statement

• H302-Harmful if swallowed.

Precautionary Statement

• P264-Wash thoroughly after handling.
• P270-Do not eat, drink or smoke when using this product.
• P301+P312-IF SWALLOWED: Call a POISON CENTER or doctor/physician/ if you feel unwell.
• P330-Rinse mouth.
• P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.

Supplemental information

• MIXTURE LIST-Contains : 3-Isobutyl-1-methylxanthine