4,5-Dimethoxy-2-nitrobenzyl chloroformate, 97%, Thermo Scientific Chemicals

Description

4,5-Dimethoxy-2-nitrobenzyl chloroformate is used as a reagent for protection of amines, for use in N-protection of bases in nucleotide synthesis, photochemical protecting groups in organic synthesis. It is used as pharmaceutical intermediate.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
4,5-Dimethoxy-2-nitrobenzyl chloroformate is used as a reagent for protection of amines, for use in N-protection of bases in nucleotide synthesis, photochemical protecting groups in organic synthesis. It is used as pharmaceutical intermediate.

Solubility
Soluble in methanol, acetone. Reacts with water.

Notes
Moisture and light sensitive. Store away from oxidizing agents, light, water/ moisture, heat, bases.

Specifications

Chemical Identifiers

• CAS: 42855-00-5
• Molecular Formula: C10H10ClNO6
• Molecular Weight (g/mol): 275.641
• MDL Number: MFCD00143507
• InChI Key: RWWPKIOWBQFXEE-UHFFFAOYSA-N
• Synonym: 4,5-dimethoxy-2-nitrobenzyl carbonochloridate, nvoc-cl, 4,5-dimethoxy-2-nitrobenzyl chloroformate, 6-nitroveratryl chloroformate, nitroveratryl oxy chlorocarbamate, 6-nitroveratryloxycarbonyl chloride, carbonochloridic acid, 4,5-dimethoxy-2-nitrophenyl methyl ester, 4,5-dimethoxy-2-nitrophenyl methyl chloroformate, 4,5-dimethoxy-2-nitrophenyl methyl carbonochloridate, nvoc chloride
• PubChem CID: 3084878
• IUPAC Name: (4,5-dimethoxy-2-nitrophenyl)methyl carbonochloridate
• SMILES: COC1=C(C=C(C(=C1)COC(=O)Cl)[N+](=O)[O-])OC

• Melting Point: ∽120°C (decomposition)
• Quantity: 1 g
• UN Number: UN3261
• Beilstein: 2389168
• Sensitivity: Light and moisture sensitive
• Solubility Information: Soluble in methanol,acetone. Reacts with water.
• Formula Weight: 275.64
• Percent Purity: 97%
• Chemical Name or Material: 4,5-Dimethoxy-2-nitrobenzyl chloroformate

Safety and Handling

Product Identifier

• 4,5-Dimethoxy-2-nitrobenzyl chloroformate

Signal Word

• Danger

Hazard Category

• Serious eye damage/eye irritation Category 1
• Skin corrosion/irritation Category 1 B

Hazard Statement

• H314-Causes severe skin burns and eye damage.
• H318-Causes serious eye damage.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P303+P361+P353-IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P310-Immediately call a POISON CENTER/doctor/.

Supplemental information

• MIXTURE LIST-Contains : 4,5-Dimethoxy-2-nitrobenzyl chloroformate

RUO – Research Use Only