4-Aminobutyric acid, 99+%, Thermo Scientific Chemicals

Description

4-Aminobutyric acid, 99+%, CAS # 56-12-2, also known as γ-Aminobutyric acid, is an amino acid that shows inhibitory activities against neurotransmitters, including GABA.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• 4-Aminobutyric acid is a γ-amino acid and monocarboxylic acid derived from butyric acid

• It is an amino acid that shows inhibitory activities against neurotransmitters, including GABA, and acts by binding GABA-A receptor and inhibiting the activity of signal-receiving neurons

• This compound, converted from neurotransmitter glutamate, is essential to regulate neuronal excitability

• It binds to GABA-A and GABA-B receptors, causing ion channel opening, hyperpolarization, and eventually inhibition of neurotransmission

Applications

• 4-Aminobutyric acid has been used in the preparation of GABA–BSA (bovine serum albumin)–GA (glutaraldehyde) conjugate, which is used as a control for immunohistochemical experiments

• It is used, in vivo, to detect GABA neurotransmitter by magnetic resonance spectroscopy

• This compound increases the production of short-chain fatty acids and decreases pH values in mouse colon

• Some in vivo experiments, using rats, mice, and pigs, demonstrated that 4-Aminobutyric acid can modulate intestinal fluid secretion, blood flow and ulceration

Specifications

Chemical Identifiers

• CAS: 56-12-2
• Molecular Formula: C₄H₉NO₂
• Molecular Weight (g/mol): 103.12
• MDL Number: MFCD00008226
• InChI Key: BTCSSZJGUNDROE-UHFFFAOYSA-N
• Synonym: 4-aminobutyric acid, gaba, gamma-aminobutyric acid, piperidic acid, piperidinic acid, aminalon, gaballon, gammalon, mielogen, butanoic acid, 4-amino
• PubChem CID: 119
• ChEBI: CHEBI:16865
• IUPAC Name: 4-aminobutanoic acid
• SMILES: C(CC(=O)O)CN

• Melting Point: 197°C to 204°C
• CAS Min %: 99.0
• CAS Max %: 100.0
• Color: White
• Infrared Spectrum: Authentic
• Assay Percent Range: 99+%
• Loss on Drying: 0.5% max.
• Packaging: Plastic Bottle
• Linear Formula: H₂N(CH₂)₃CO₂H
• Beilstein: 04,413
• Merck Index: 15,425
• Transmittance: 95% min. (c=10, 2N HCl, 430nm) 1cm cell
• Solubility Information: Solubility in water: very soluble. Other solubilities: slightly soluble in common solvents
• Quantity: 25 g
• Formula Weight: 103.12
• Percent Purity: ≥99%
• Physical Form: Crystalline Powder
• Chemical Name or Material: 4-Aminobutyric acid, 99+%

Safety and Handling

Product Identifier

• 4-Aminobutyric acid

RUO – Research Use Only