missing translation for 'onlineSavingsMsg'
Learn More

4-(Chloromethyl)pyridine hydrochloride, 98%, Thermo Scientific Chemicals

Product Code. 11475273
Click to view available options
Quantity:
5 g
25 g
100 g
This item is not returnable. View return policy
This item is not returnable. View return policy

It finds its application as a reagent for protection of carboxyl termini of peptides as 4-picolyl esters, providing a polar 'handle' which aids in separation and purification of the peptide. The group can be introduced in the presence of a base, e.g. tetramethylguanidine, is stable to acid-catalyzed removal of Cbz protecting group and can be removed by base, Na in liquid ammonia or catalytic hydrogenolysis. It is also applied in conjunction with Amberlyst™15 resin in peptide synthesis. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
It finds its application as a reagent for protection of carboxyl termini of peptides as 4-picolyl esters, providing a polar ′handle′ which aids in separation and purification of the peptide. The group can be introduced in the presence of a base, e.g. tetramethylguanidine, is stable to acid-catalyzed removal of Cbz protecting group and can be removed by base, Na in liquid ammonia or catalytic hydrogenolysis. It is also applied in conjunction with Amberlyst™15 resin in peptide synthesis. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.

Solubility
Soluble in water (750 mg/ml at 20°C), soluble in 1N HCl (2.5%), DMSO, and methanol.

Notes
Hygroscopic. Store away from oxidizing agents and bases. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 1822-51-1
Molecular Formula C6H7Cl2N
Molecular Weight (g/mol) 164.029
MDL Number MFCD00012826
InChI Key ZDHKVKPZQKYREU-UHFFFAOYSA-N
Synonym 4-chloromethyl pyridine hydrochloride, 4-picolyl chloride hydrochloride, 4-chloromethyl pyridinium chloride, 4-chloromethylpyridine hydrochloride, 4-chloromethyl-pyridine hydrochloride, ccris 1728, isonicotinyl chloride hydrochloride, pyridine, 4-chloromethyl-, hydrochloride, 4-chloromethyl pyridine hcl, 4-chloromethyl pyridine, chloride
PubChem CID 74570
IUPAC Name 4-(chloromethyl)pyridine;hydrochloride
SMILES C1=CN=CC=C1CCl.Cl

Specifications

Melting Point 166°C to 171°C
Quantity 5 g
UN Number UN3261
Beilstein 3689154
Sensitivity Hygroscopic
Solubility Information Soluble in water (750mg/ml at 20°C),soluble in 1N HCl (2.5%),DMSO,and methanol.
Formula Weight 164.04
Percent Purity 98%
Chemical Name or Material 4-(Chloromethyl)pyridine hydrochloride

RUO – Research Use Only

Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.