4-(Chloromethyl)pyridine hydrochloride, 98%, Thermo Scientific Chemicals

Description

It finds its application as a reagent for protection of carboxyl termini of peptides as 4-picolyl esters, providing a polar 'handle' which aids in separation and purification of the peptide. The group can be introduced in the presence of a base, e.g. tetramethylguanidine, is stable to acid-catalyzed removal of Cbz protecting group and can be removed by base, Na in liquid ammonia or catalytic hydrogenolysis. It is also applied in conjunction with Amberlyst™15 resin in peptide synthesis. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
It finds its application as a reagent for protection of carboxyl termini of peptides as 4-picolyl esters, providing a polar ′handle′ which aids in separation and purification of the peptide. The group can be introduced in the presence of a base, e.g. tetramethylguanidine, is stable to acid-catalyzed removal of Cbz protecting group and can be removed by base, Na in liquid ammonia or catalytic hydrogenolysis. It is also applied in conjunction with Amberlyst™15 resin in peptide synthesis. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.

Solubility
Soluble in water (750 mg/ml at 20°C), soluble in 1N HCl (2.5%), DMSO, and methanol.

Notes
Hygroscopic. Store away from oxidizing agents and bases. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Specifications

Chemical Identifiers

• CAS: 1822-51-1
• Molecular Formula: C6H7Cl2N
• Molecular Weight (g/mol): 164.029
• MDL Number: MFCD00012826
• InChI Key: ZDHKVKPZQKYREU-UHFFFAOYSA-N
• Synonym: 4-chloromethyl pyridine hydrochloride, 4-picolyl chloride hydrochloride, 4-chloromethyl pyridinium chloride, 4-chloromethylpyridine hydrochloride, 4-chloromethyl-pyridine hydrochloride, ccris 1728, isonicotinyl chloride hydrochloride, pyridine, 4-chloromethyl-, hydrochloride, 4-chloromethyl pyridine hcl, 4-chloromethyl pyridine, chloride
• PubChem CID: 74570
• IUPAC Name: 4-(chloromethyl)pyridine;hydrochloride
• SMILES: C1=CN=CC=C1CCl.Cl

• Melting Point: 166°C to 171°C
• Quantity: 100 g
• UN Number: UN3261
• Beilstein: 3689154
• Sensitivity: Hygroscopic
• Solubility Information: Soluble in water (750mg/ml at 20°C),soluble in 1N HCl (2.5%),DMSO,and methanol.
• Formula Weight: 164.04
• Percent Purity: 98%
• Chemical Name or Material: 4-(Chloromethyl)pyridine hydrochloride

RUO – Research Use Only