4-(Dimethylamino)pyridine, 99%, Thermo Scientific Chemicals

Description

4-(Dimethylamino)pyridine is a useful nucleophilic catalyst for various reactions viz. esterifications with anhydrides, the Baylis-Hillman reaction, hydrosilylations, tritylation and Steglich rearrangement. It is also an effective catalyst for transesterification of beta-keto esters and silylation of alcohols.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
4-(Dimethylamino)pyridine is a useful nucleophilic catalyst for various reactions viz. esterifications with anhydrides, the Baylis-Hillman reaction, hydrosilylations, tritylation and Steglich rearrangement. It is also an effective catalyst for transesterification of beta-keto esters and silylation of alcohols.

Solubility
Soluble in methanol, benzene, ethyl acetate, chloroform, methylene chloride, acetone, and acetic acid. Slightly soluble in ether, diisopropyl ether, cyclohexane, hexane, and water.

Notes
Incompatible with strong oxidizing agents and strong acids.

Specifications

Chemical Identifiers

• CAS: 1122-58-3
• Molecular Formula: C7H10N2
• Molecular Weight (g/mol): 122.171
• MDL Number: MFCD00006418
• InChI Key: VHYFNPMBLIVWCW-UHFFFAOYSA-N
• Synonym: 4-dimethylaminopyridine, dmap, 4-dimethylamino pyridine, 4-pyridinamine, n,n-dimethyl, n,n-dimethyl-4-pyridinamine, p-dimethylaminopyridine, pyridine, 4-dimethylamino, ccris 6176, dimethylpyridin-4-ylamine
• PubChem CID: 14284
• IUPAC Name: N,N-dimethylpyridin-4-amine
• SMILES: CN(C)C1=CC=NC=C1

• Melting Point: 110°C to 113°C
• Boiling Point: 162°C (50 mmHg)
• Flash Point: 124°C (255°F)
• Assay Percent Range: 99%
• Quantity: 25 g
• UN Number: UN2928
• Beilstein: 110354
• Solubility Information: Soluble in methanol,benzene,ethyl acetate,chloroform,methylene chloride,acetone,and acetic acid. Slightly soluble in ether,diisopropyl ether,cyclohexane,hexane,and water.
• Formula Weight: 122.17
• Percent Purity: 99%
• Chemical Name or Material: 4-Dimethylaminopyridine

Safety and Handling

Product Identifier

• 4-(Dimethylamino)pyridine

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 2
• Acute toxicity Category 3
• LONG-TERM AQUATIC HAZARD Chronic 2
• Serious eye damage/eye irritation Category 1
• Skin corrosion/irritation Category 2
• Specific target organ toxicity after single exposure Category 1

Hazard Statement

• H301-Toxic if swallowed.
• H310-Fatal in contact with skin.
• H315-Causes skin irritation.
• H318-Causes serious eye damage.
• H331-Toxic if inhaled.
• H370-Causes damage to organs.
• H411-Toxic to aquatic life with long lasting effects.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P308+P313-IF exposed or concerned: Get medical advice/attention.
• P310-Immediately call a POISON CENTER/doctor/.

Supplemental information

• MIXTURE LIST-Contains : 4-(Dimethylamino)pyridine

RUO – Research Use Only