5-Fluorouracil, 99%, Thermo Scientific Chemicals

Description

5-Fluorouracil is used as an antitumor agent in the treatment of anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers. It finds application as a suicide inhibitor due to its irreversible inhibition of thymidylate synthase. It is also used in the treatment of actinic keratoses and bowen's disease. Further, it serves as a potent antineoplastic agent in clinical use. In addition to this, it acts as a DNA synthesis inhibitor.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in dimethylformamide, dimethyl sulfoxide, methanol, hot water, ammonium hydroxide, sodium hydroxide, ethanol and water.

Notes
Store in a cool place. Incompatible with strong oxidizing agents and strong bases.

Specifications

Chemical Identifiers

• CAS: 51-21-8
• Molecular Formula: C4H3FN2O2
• Molecular Weight (g/mol): 130.08
• MDL Number: MFCD00006018
• InChI Key: GHASVSINZRGABV-UHFFFAOYSA-N
• Synonym: 5-fluorouracil, fluorouracil, 5-fu, fluoroplex, adrucil, efudex, carac, fluracil, fluoroblastin, kecimeton
• PubChem CID: 3385
• ChEBI: CHEBI:46345
• IUPAC Name: 5-fluoro-1H-pyrimidine-2,4-dione
• SMILES: FC1=CNC(=O)NC1=O

• Melting Point: ∽282°C (decomposition)
• Assay Percent Range: 99%
• Quantity: 5 g
• UN Number: UN2811
• Beilstein: 127172
• Sensitivity: Light sensitive
• Merck Index: 14,4181
• Solubility Information: Soluble in dimethylformamide,dimethyl sulfoxide,methanol,hot water,ammonium hydroxide,sodium hydroxide,ethanol and water.
• Formula Weight: 130.08
• Percent Purity: 99%
• Chemical Name or Material: 5-Fluorouracil

Safety and Handling

Product Identifier

• 5-Fluorouracil

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 3
• Acute toxicity Category 4
• Serious eye damage/eye irritation Category 2
• Germ cell mutagenicity Category 2
• Reproductive toxicity Category 2
• Skin corrosion/irritation Category 2
• Specific target organ toxicity Category 3

Hazard Statement

• H301-Toxic if swallowed.
• H312-Harmful in contact with skin.
• H315-Causes skin irritation.
• H319-Causes serious eye irritation.
• H332-Harmful if inhaled.
• H335-May cause respiratory irritation.
• H341-Suspected of causing genetic defects.
• H361d-Suspected of damaging the unborn child.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P332+P313-If skin irritation occurs: Get medical advice/attention.
• P337+P313-If eye irritation persists: Get medical advice/attention.

Supplemental information

• MIXTURE LIST-Contains : Fluorouracil

RUO – Research Use Only