5-Fluorouracil, Tocris Bioscience™

Description

Thymidylate synthetase inhibitor

Anticancer agent. Metabolized to form fluorodeoxyuridine monophosphate (FdUMP), fluorodeoxyuridine triphosphate (FdUTP) and fluorouridine (FUTP). FdUMP inhibits thymidylate synthase, causing a reduction in dTMP synthesis. FUTP and FdUTP are misincorporated into RNA and DNA respectively.

Specifications

• CAS: 51-21-8
• Molecular Formula: C4H3FN2O2
• MDL Number: MFCD00006018
• Quantity: 50 mg
• Synonym: 5-fluorouracil, fluorouracil, 5-fu, fluoroplex, adrucil, efudex, carac, fluracil, fluoroblastin, kecimeton
• InChI Key: GHASVSINZRGABV-UHFFFAOYSA-N
• SMILES: FC1=CNC(=O)NC1=O
• IUPAC Name: 5-fluoro-1,2,3,4-tetrahydropyrimidine-2,4-dione
• Molecular Weight (g/mol): 130.08
• PubChem CID: 3385
• ChEBI: CHEBI:46345
• Formula Weight: 130.08
• Percent Purity: >99%
• Chemical Name or Material: 5-Fluorouracil