Tocris Bioscience™ GNE 2861

Inhibitor of group II p21 activated kinases

Brand:  Tocris Bioscience™ 6490/5

Product Code. 18709016

Description

GNE 2861 is an inhibitor of group II p21 activated kinases (PAK; IC50 values are 7.5, 126 and 36 nM for PAK4, PAK5 and PAK6, respectively). Displays selectivity for group II PAK over a panel of 222 kinases. Inhibits tumor cell proliferation, migration and invasion in two breast cancer cell lines. Also sensitizes tamoxifen-resistant breast cancer cell lines to tamoxifen (Cat. No. 6342) via PAK4-dependent regulation of estrogen receptor α (ERα) target gene expression.

Specifications

• Chemical Name or Material: 1-[2-[1-(2-Amino-4-pyrimidinyl)-2-[(2-methoxyethyl)amino]-1H-benzimidazol-6-yl]ethynyl]cyclohexanol
• Quantity: 5 mg
• Formula Weight: 406.48

• CAS: 1394121-05-1
• Molecular Formula: C₂₂H₂₆N₆O₂
• Purity: 98%