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  7. 6,7-Dihydroxycoumarin, 98+%, Thermo Scientific Chemicals

6,7-Dihydroxycoumarin, 98+%, Thermo Scientific Chemicals

Product Code. 11488346
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Quantity:
1 g
5 g
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.

Solubility
Soluble in DMSO, DMF, diluted alkalies with blue fluorescence, and acetone. Slightly soluble in water. Insoluble in ether. Moderately soluble in Glacial acetic acid, and hot ethanol.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agents.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 305-01-1
Molecular Formula C9H6O4
Molecular Weight (g/mol) 178.143
MDL Number MFCD00006874
InChI Key ILEDWLMCKZNDJK-UHFFFAOYSA-N
Synonym esculetin, 6,7-dihydroxycoumarin, aesculetin, cichorigenin, 6,7-dihydroxy-2h-chromen-2-one, cichoriin aglucon, esculatin, esculetol, esculin aglucon, esculin aglycon
PubChem CID 5281416
ChEBI CHEBI:490095
IUPAC Name 6,7-dihydroxychromen-2-one
SMILES C1=CC(=O)OC2=CC(=C(C=C21)O)O

Specifications

Melting Point ∼270°C (decomposition)
Quantity 5 g
Beilstein 152788
Merck Index 14,3697
Solubility Information Soluble in DMSO,DMF,diluted alkalies with blue fluorescence,and acetone. Slightly soluble in water. Insoluble in ether. Moderately soluble in Glacial acetic acid,and hot ethanol.
Formula Weight 178.15
Percent Purity ≥98%
Chemical Name or Material 6,7-Dihydroxycoumarin

RUO – Research Use Only

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