6-Thioguanine, Tocris Bioscience™

Description

Anticancer and immunosuppressive agent

Anticancer and immunosuppressive agent often used to treat immune disorders and leukemia. Displays cytotoxic and antineoplastic properties; disrupts cytosine methylation by DNA methyltransferases after incorporation into DNA. Selectively kills BRCA2-defective tumors in a xenograft model. Also facilitates proteasome-mediated degradation of DNA (cytosine-5)-methyltransferase 1 (DNMT1). Also inhibits SARS-CoV papain-like protease (PLpro; IC50 = 5 μM for PLpro deubiquitination activity).

Specifications

• CAS: 154-42-7
• Molecular Formula: C5H5N5S
• MDL Number: MFCD00233553
• Quantity: 50 mg
• Synonym: 6-thioguanine, thioguanine, tioguanine, 2-amino-6-mercaptopurine, 6-mercaptoguanine, tioguanin, tabloid, lanvis, 2-amino-6-purinethiol, 2-aminopurine-6-thiol
• InChI Key: WYWHKKSPHMUBEB-UHFFFAOYSA-N
• SMILES: NC1=NC(=S)C2=C(N1)N=CN2
• IUPAC Name: 2-amino-6,7-dihydro-3H-purine-6-thione
• Molecular Weight (g/mol): 167.19
• PubChem CID: 2723601
• ChEBI: CHEBI:9555
• Formula Weight: 167.19
• Percent Purity: >99%
• Chemical Name or Material: 6-Thioguanine