7,8-Dihydroxyflavone, Tocris Bioscience™

Description

TrkB agonist

Tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor (Kd = 320 nM). Inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro and in vivo. Exhibits neuroprotective effects in an HD mouse model.

Specifications

Chemical Identifiers

• CAS: 38183-03-8
• Molecular Formula: C15H10O4
• Molecular Weight (g/mol): 254.24
• MDL Number: MFCD00006836
• InChI Key: COCYGNDCWFKTMF-UHFFFAOYSA-N
• Synonym: 7,8-dihydroxyflavone, 7,8-dihydroxy-2-phenyl-4h-chromen-4-one, 7,8-dihydroxy-flavone, 4h-1-benzopyran-4-one, 7,8-dihydroxy-2-phenyl, 7,8-dhf, 7,8-dihydroxy-2-phenyl-4-benzopyrone, 7,8-dihydroxy-2-phenyl-chromen-4-one, 7,8-dihydroxyflavone hydrate, chembl75267, 7,8-dihydroxy-2-phenyl-4h-1-benzopyran-4-one
• PubChem CID: 1880
• IUPAC Name: 7,8-dihydroxy-2-phenyl-4H-chromen-4-one
• SMILES: OC1=CC=C2C(=O)C=C(OC2=C1O)C1=CC=CC=C1

• Quantity: 50 mg
• Formula Weight: 254.24
• Percent Purity: >98%
• Chemical Name or Material: 7, 8-Dihydroxyflavone