8-pCPT-2-O-Me-cAMP-AM, Tocris Bioscience™

Description

Selective Epac activator; cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645)

Selective Epac activator; cAMP analog. Induces Rap activation and junction tightening in HUVECs; triggers adhesion of Jurkat-Epac1 cells to fibronectin. Stimulates insulin secretion in rat INS-1 cells. More potent, cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645).

This product is a mixture of axial and equatorial isomers. Both isomers give 8CPT-2Me-cAMP after esterase cleavage.

Specifications

• CAS: 1152197-23-3
• Molecular Formula: C20H21ClN5O8PS
• Quantity: 100 μg
• Synonym: 8-pcpt-2-o-me-camp-am, 8-cpt-am, 8-4-chlorophenylthio-2'-o-methyladenosine-3',5'-cyclic monophosphate acetoxymethyl ester
• InChI Key: FZMWUFYPEVDWPA-SILPBKOMSA-N
• SMILES: CC(=O)OCOP1(=O)OCC2C(O1)C(C(O2)N3C4=C(C(=NC=N4)N)N=C3SC5=CC=C(C=C5)Cl)OC
• IUPAC Name: [(4aR,6R,7R,7aR)-6-[6-amino-8-(4-chlorophenyl)sulfanylpurin-9-yl]-7-methoxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-yl]oxymethyl acetate
• Molecular Weight (g/mol): 557.899
• PubChem CID: 90488978
• Formula Weight: 557.9
• Percent Purity: >97%
• Chemical Name or Material: EPAC Activators