9-Fluorenylmethyl chloroformate, 98+%, Thermo Scientific Chemicals

Description

Store cold

Base sensitive amino protecting group for solid-phase peptide synthesis9-Fluorenylmethyl chloroformate is used in capillary electrophoresis. It acts as a reagent in the precolumn derivatization of amines for HPLC and fluorescent detection. Further, it is used for derivatizing amino acids for HPLC analysis. In addition to this, it is used to prepare N-Fmoc amino acids for solid-phase peptide synthesis and oligonucleotide synthesis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Base sensitive amino protecting group for solid-phase peptide synthesis9-Fluorenylmethyl chloroformate is used in capillary electrophoresis. It acts as a reagent in the precolumn derivatization of amines for HPLC and fluorescent detection. Further, it is used for derivatizing amino acids for HPLC analysis. In addition to this, it is used to prepare N-Fmoc amino acids for solid-phase peptide synthesis and oligonucleotide synthesis.

Solubility
Soluble in dioxane.

Notes
Moisture sensitive. Store in a cool place. Incompatible with alcohols and amines.

Specifications

Chemical Identifiers

• CAS: 28920-43-6
• Molecular Formula: C15H11ClO2
• Molecular Weight (g/mol): 258.701
• MDL Number: MFCD00001138
• InChI Key: IRXSLJNXXZKURP-UHFFFAOYSA-N
• Synonym: 9-fluorenylmethyl chloroformate, fmoc-cl, fmoc-chloride, fmoc chloride, 9h-fluoren-9-ylmethyl chloroformate, carbonochloridic acid, 9h-fluoren-9-ylmethyl ester, 9-fluorenylmethoxycarbonyl chloride, 9-fluorenylmethylchloroformate, 9h-fluoren-9-yl methyl carbonochloridate, 9h-fluoren-9-ylmethoxy carbonyl chloride
• PubChem CID: 34367
• IUPAC Name: 9H-fluoren-9-ylmethyl carbonochloridate
• SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)Cl

• Melting Point: 60°C to 64°C
• Assay Percent Range: 98%
• Quantity: 5 g
• UN Number: UN2923
• Beilstein: 2279177
• Sensitivity: Moisture sensitive
• Solubility Information: Soluble in dioxane.
• Formula Weight: 258.7
• Percent Purity: 98%
• Chemical Name or Material: 9-Fluorenylmethyl Chloroformate

Safety and Handling

Product Identifier

• 9-Fluorenylmethyl chloroformate

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 4
• Serious eye damage/eye irritation Category 1
• Skin corrosion/irritation Category 1 B

Hazard Statement

• H302-Harmful if swallowed.
• H312-Harmful in contact with skin.
• H314-Causes severe skin burns and eye damage.
• H318-Causes serious eye damage.
• H332-Harmful if inhaled.
• EUH029-Contact with water liberates toxic gas.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P310-Immediately call a POISON CENTER/doctor/.

Supplemental information

• MIXTURE LIST-Contains : 9-Fluorenylmethyl chloroformate

RUO – Research Use Only