Tocris Bioscience™ (+/-)-a-Lipoamide, Liquid-Liquid Phase Separated

Liquid-liquid phase separated condensate modifier; reduces stress granule formation

Brand:  Tocris Bioscience™ 7044/100

Product Code. 18749406

Description

(±)-α-Lipoic acid (ALA) is a liquid-liquid phase separated condensate modifier. Reduces stress granule formation in HeLa cells. Also stimulates mitochondrial biogenesis in 3T3-L1 adipocytes. Prevents dieback of FUS mutant motor neurons in culture and reverses motor defects in D. melanogaster expressing mutated human FUS. (±)-α-Lipoic acid is also an antixocidant. In hematopoietic stem cells (HSC) (±)-α-Lipoic acid reduces levels of reactive oxygen species (ROS) and inhibits apoptosis. It also promotes the generation of hematopoietic stem/progenitor cells from hPSCs in vitro and maintenance of functional cord blood HSCs ex vivo.

Specifications

• Chemical Name or Material: 1,2-Dithiolane-3-pentanoic acid
• Quantity: 100 mg
• Purity: 98%

• CAS: 1077-28-7
• Molecular Formula: C₈H₁₄O₂S₂