Tocris Bioscience™ a-Synuclein Degrader 2b

α-synuclein Degrader (PROTAC™)

Brand:  Tocris Bioscience™ 8040/5

Product Code. 18704444

Description

α-Synuclein Degrader 2b is a selective α-synuclein Degrader (PROTAC™) (DC50 = 7.5 μM; Dmax = 89%). Comprises the probe molecule sery308, joined by a linker to a pomalidomide E3 ligase ligand. Activates both proteasomal and lysosomal degradation pathways. Protects SH-SY5Y cells from α-synuclein-induced cytotoxicity. Cell permeable.PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

• Chemical Name or Material: 2-[[3-[5-(1,3-Benzodioxol-5-yl)-1H-pyrazol-3-yl]phenyl]amino]-N-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]acetamide
• Quantity: 5 mg
• Molecular Formula: C₃₉H₄₁N₇O₁₀

• CAS: 2781922-42-5
• Target: Active Degraders
• Purity: 0.98