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Tocris Bioscience™ Ac-Cys-NHMe
Building block for the lysine acylation using conjugating enzymes (LACE) technique
£117.71 - £455.71
Specifications
| Chemical Name or Material | (2R)-2-(Acetylamino)-3-mercapto-N-methylpropanamide |
|---|---|
| CAS | 10061-65-1 |
| Target | Unnatural Amino Acids |
| Molecular Formula | C6H12N2O2S |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
30000012
|
Tocris Bioscience™
7936/10 |
10 mg |
£117.71
10mg |
Estimated Shipment: 29-07-2024 Log in to see stock. |
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|
30000025
|
Tocris Bioscience™
7936/50 |
50 mg |
£455.71
50mg |
Estimated Shipment: 29-07-2024 Log in to see stock. |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
Description
Ac-Cys-NHMe is a non-canonical amino acid that is an essential building block for lysine acylation using conjugating enzymes (LACE) technique. LACE is a chemoenzymatic approach that uses an E2 small ubiquitin-like modifier (SUMO)-conjugating enzyme, Ubc9, to conjugate peptide thioesters containing a C-terminal ubiquitin-derived sequence (LRLRGG) to a lysine residue located in a recognition sequence (IKQE) on a protein via an isopeptide bond. Ac-Cys-NHMe can be reacted with a peptide hydrazide to form a reactive peptide thioester, which is the substrate for Ubc9. LACE enables the site-specific modification of proteins at lysine residues to allow attachment of biochemical probes such as fluorophores to proteins or to engineer proteins for site-specific delivery.Specifications
| (2R)-2-(Acetylamino)-3-mercapto-N-methylpropanamide | |
| 10061-65-1 | |
| Unnatural Amino Acids | |
| C6H12N2O2S |