ACET, Tocris Bioscience™

Description

Potent kainate antagonist; displays selectivity for GluK1-containing receptors

Potent and selective GluK1 (formerly GluR5) containing kainate receptor antagonist (IC50 = 7 nM) that displays selectivity over GluK2 (formerly GluR6) containing kainate, NMDA, AMPA and group I mGlu receptors. Reversibly blocks induction of NMDA receptor-independent long term potentiation (LTP) in vitro at nanomolar concentrations.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Specifications

• CAS: 936095-50-0
• Molecular Formula: C20H21N3O6S
• Quantity: 10 mg
• Synonym: (S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxy-5-phenylthiophene-3-yl-methyl)-5-methylpyrimidine-2, 4-dione
• InChI Key: OAAMYRWMIRGBQF-UHFFFAOYSA-N
• SMILES: CC1CN(C(=O)N(C1=O)CC2=C(SC(=C2)C3=CC=CC=C3)C(=O)O)CC(C(=O)O)N
• IUPAC Name: 3-[[3-(2-amino-2-carboxyethyl)-5-methyl-2,6-dioxo-1,3-diazinan-1-yl]methyl]-5-phenylthiophene-2-carboxylic acid
• Molecular Weight (g/mol): 431.463
• PubChem CID: 118797384
• Formula Weight: 429.45
• Percent Purity: >98%
• Chemical Name or Material: ACET