ACHP, Tocris Bioscience™

Description

Selective IKKα and IKKβ inhibitor

IκB kinase inhibitor (IC50 values are 8.5 and 250 nM for IKKβ and IKKα respectively). Selective for IKKα and IKKβ over IKK3, Syk and MAPKKK4 (IC50 values are > 20 μM). Inhibits DNA binding activity of NF-κB. Blocks NF-κB pathway in multiple myeloma cell lines; induces cell growth arrest and apoptosis.

Specifications

• CAS: 406208-42-2
• Molecular Formula: C21H24N4O2
• Quantity: 10 mg
• Synonym: achp, 2-amino-6-2-cyclopropylmethoxy-6-hydroxyphenyl-4-4-pipe
• InChI Key: DWQVGCQPWXKRKO-JZJYNLBNSA-N
• SMILES: C1CC1COC2=CC=CC(=O)C2=C3C=C(C(=C(N3)N)C#N)C4CCNCC4
• IUPAC Name: (6E)-2-amino-6-[2-(cyclopropylmethoxy)-6-oxocyclohexa-2,4-dien-1-ylidene]-4-piperidin-4-yl-1H-pyridine-3-carbonitrile
• Molecular Weight (g/mol): 364.449
• PubChem CID: 22258733
• Formula Weight: 364.44
• Percent Purity: >97%
• Chemical Name or Material: ACHP