Adapalene, Tocris Bioscience™

Description

RARβ and RARγ agonist

Retinoic acid analog that is a RARβ and RARγ agonist (AC50 values are 2.2, 9.3, 22 and > 1000 nM for RARβ, RARγ, RARα and RXRα receptors respectively). Inhibits proliferation and induces apoptosis in colorectal cancer cell in vitro. Displays comedolytic activity.

Specifications

Chemical Identifiers

• CAS: 106685-40-9
• Molecular Formula: C28H28O3
• Molecular Weight (g/mol): 412.529
• InChI Key: LZCDAPDGXCYOEH-UHFFFAOYSA-N
• Synonym: adapalene, differin, adapalenum, adapaleno, adapaleno inn-spanish, adaferin, 6-3-adamantan-1-yl-4-methoxyphenyl-2-naphthoic acid, adapalenum inn-latin, differine, 6-3-1-adamantyl-4-methoxyphenyl-2-naphthoic acid
• PubChem CID: 60164
• ChEBI: CHEBI:31174
• IUPAC Name: 6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid
• SMILES: COC1=C(C=C(C=C1)C2=CC3=C(C=C2)C=C(C=C3)C(=O)O)C45CC6CC(C4)CC(C6)C5

• Quantity: 50 mg
• Formula Weight: 412.52
• Percent Purity: >98%
• Chemical Name or Material: Adapalene