STEMCELL Technologies AKT Inhibitor VIII

PI3K/AKT pathway inhibitor; Inhibits AKT1, AKT2, and AKT3

Product Code	Brand	Quantity
17110152	STEMCELL Technologies 72942	1 mg
17120152	STEMCELL Technologies 72944	10 mg

Description

• AKT Inhibitor VIII is a cell-permeable, allosteric inhibitor of all three forms of the kinase AKT (AKT1, AKT2, and AKT3) with IC₅₀ values of 58, 210, and 2,200 nM, respectively (Lindsley et al.; Calleja et al.) It displays good selectivity against a panel of 70 other kinases with micromolar inhibition against some kinases, such as calcium/calmodulin-dependent protein kinase 1 and smooth muscle myosin light-chain kinase (Logie et al.)
• Sensitizes prostate tumor and cervical carcinoma cells to apoptotic stimuli (DeFeo-Jones et al.)
• Blocks mitosis and inhibits migration of HeLa cells (Jo et al.)
• Reduces insulin-dependent gene repression in liver cells leading to reduced insulin sensitivity (Logie et al.)

Specifications

• CAS: 612847-09-3
• Synonym: AKTi-1/2; AKT 1/2 inhibitor
• Molecular Formula: C₃₄H₂₉N₇O
• Purity: ≥98%