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alpha Synuclein Monoclonal Antibody (4B12), Invitrogen™
Mouse Monoclonal Antibody
Brand: Invitrogen MA190346
This item is not returnable.
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Description
Predicted molecular weight of 16 kDa.
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.
Specifications
| alpha Synuclein | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 0.1% sodium azide | |
| P37840 | |
| SNCA | |
| Recombinant human alpha synuclein produced in E. coli. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Dot Blot, ELISA, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot | |
| 4B12 | |
| Unconjugated | |
| SNCA | |
| Alpha synuclein; alphaSYN; alpha-synuclein; NACP; non A-beta component of AD amyloid; non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; Snca; Syn; synuclein alpha; synuclein alpha-140; synuclein, alpha; synuclein, alpha (non A4 component of amyloid precursor) | |
| Mouse | |
| Ammonium sulfate precipitation | |
| RUO | |
| 6622 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |