Cytokeratin Pan Type I Monoclonal Antibody (AE1), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA513144

Product Code. 11304793

Description

MA5-13144 targets Cytokeratin Low Molecular Weight in WB, IF and IHC (P) applications and shows reactivity with Bovine, Chicken, Human, mouse, Non-human primate, Rabbit, and Rat samples. This antibody is not recommended for NIH-3T3 cells in immunofluorescent applications. The MA5-13144 immunogen is human epidermal keratin.

Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.

Specifications

• Antigen: Cytokeratin Pan Type I
• Classification: Monoclonal
• Concentration: 0.2 mg/mL
• Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
• Gene Accession No.: O93256, P02533, P02535, P04104, P04264, P05783, P05784, P05785, P05786, P05787, P06394, P08727, P08728, P08779, P11679, P13645, P19001, P19012, P35527, Q10758, Q5BJY9, Q61414, Q61781, Q63279, Q6IFV1, Q6IFV3, Q6IFW6, Q6IMF3, Q6PVZ1, Q6RHW0, Q8CIS9, Q9Z2K1
• Gene Symbols: KRT1, KRT10, Krt14, KRT15, KRT16, KRT18, KRT19, KRT8, KRT9
• Immunogen: Human epidermal keratin
• Quantity: 500 μL
• Primary or Secondary: Primary
• Target Species: Bovine, Chicken, Human, Mouse, Non-human Primate, Rabbit, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Clone: AE1
• Conjugate: Unconjugated
• Gene: KRT10
• Gene Alias: 40-kDa keratin intermediate filament; 56 kDa cytokeratin; 67 kDa cytokeratin; AA960620; AI324768; AI528832; AI626930; AI663979; AL022697; alpha keratin; AU019895; BCIE; BIE; Card2; Cell proliferation-inducing gene 46 protein; CK1; CK-1; CK10; CK-10; CK14; CK-14; CK15; CK-15; CK16; CK-16; CK18; CK-18; CK19; CK-19; CK8; CK-8; CK-9; CYK18; CYK8; CYKER; cytokeratin 1; cytokeratin 10; cytokeratin 14; cytokeratin 15; cytokeratin 16; cytokeratin 18; cytokeratin 19; cytokeratin 8; cytokeratin 8 (370 AA); cytokeratin 9; cytokeratin endo A; Cytokeratin endo B; cytokeratin VIB; cytokeratin VII; Cytokeratin-1; Cytokeratin-10; cytokeratin-14; Cytokeratin-15; cytokeratin-16; Cytokeratin-18; cytokeratin-19; Cytokeratin-6B; cytokeratin-7; cytokeratin-8; Cytokeratin-9; cytokeratin-A; D130054E02Rik; EBS3; EBS4; EGK_03685; EHK; EHK1; Endo B; EndoA; EndoC; epidermal keratin 10; epidermal keratin VII; epidermolysis bullosa simplex, Dowling-Meara, Koebner; epidermolytic hyperkeratosis 1; epidermolytic hyper
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 100009029, 100138169, 100301161, 100341120, 100341376, 100348891, 100353415, 100354174, 101749333, 107656, 16661, 16664, 16665, 16666, 16668, 16669, 16678, 16691, 25626, 266717, 281269, 281888, 287700, 287701, 294853, 300250, 303530, 360626, 3848, 3856, 3857, 3858, 3861, 3866, 3868, 3875, 3880, 395861, 404111, 408039, 408040, 426896, 450225, 506480, 507464, 514812, 771977, 788727
• Content And Storage: 4° C
• Form: Liquid