PR3 Monoclonal Antibody (3B4), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA515540

Product Code. 11365503

Description

MA5-15540 targets Proteinase 3 in indirect ELISA, WB applications and shows reactivity with Human samples. The MA5-15540 immunogen is purified recombinant fragment of human Proteinase 3 expressed in E. Coli. MA5-15540 detects Proteinase 3 which has a predicted molecular weight of approximately 28kDa.

Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279). [UniProt]

Specifications

• Antigen: PR3
• Classification: Monoclonal
• Concentration: 1.0 mg/mL
• Formulation: PBS with 50% glycerol and 0.03% sodium azide
• Gene Accession No.: P24158
• Gene Symbols: PRTN3
• Immunogen: Purified recombinant fragment of human Proteinase 3 expressed in E. Coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: ELISA, Western Blot
• Clone: 3B4
• Conjugate: Unconjugated
• Gene: PRTN3
• Gene Alias: ACPA; AGP7; azurophil granule protein 7; CANCA; C-ANCA; C-ANCA antigen; leukocyte proteinase 3; MBN; MBT; mPR3; Myeloblastin; neutrophil proteinase 4; NP4; NP-4; P29; PR3; PR-3; Proteinase 3; PRTN3; serine proteinase, neutrophil; wegener autoantigen; Wegener granulomatosis autoantigen
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 5657
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid