API-1, Tocris Bioscience™

Description

Selective Akt/PKB inhibitor. Antitumor

Akt/protein kinase B (PKB) inhibitor. Binds the pleckstrin homology domain of Akt and blocks Akt membrane translocation. Inhibits EGF-induced kinase activity of Akt1, Akt2 and Akt3. Induces cell growth arrest and apoptosis in human cancer cells expressing constitutively active Akt. Displays antitumor activity in vitro and in vivo.

Specifications

• CAS: 36707-00-3
• Molecular Formula: C13H15N5O6
• Quantity: 10 mg
• Synonym: api-1, 4-amino-8-3,4-dihydroxy-5-hydroxymethyl oxolan-2-yl-5-oxo, 4-amino-5,8-dihydro-5-oxo-8-?-d-ribofuranosyl-pyrido 2,3-d pyrimidine-6-carboxamide, 4-amino-5,8-dihydro-5-oxo-8-beta-d-ribofuranosyl-pyrido 2,3-d pyrimidine-6-carboxamide, 4-amino-8-2r,3r,4s,5r-3,4-dihydroxy-5-hydroxymethyl oxolan-2-yl-5-oxopyrido 2,3-d pyrimidine-6-carboxamide
• InChI Key: SPBWHPXCWJLQRU-FITJORAGSA-N
• SMILES: C1=C(C(=O)C2=C(N1C3C(C(C(O3)CO)O)O)N=CN=C2N)C(=O)N
• IUPAC Name: 4-amino-8-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamide
• Molecular Weight (g/mol): 337.292
• PubChem CID: 24773090
• Formula Weight: 337.29
• Percent Purity: >96%
• Chemical Name or Material: API-1