AQ-RA 741, Tocris Bioscience™

Description

Selective, high affinity M2 antagonist

High affinity, selective muscarinic M2 receptor antagonist (pKi values are 8.3, 7.7 and 6.82 for M2, M1 and M3 receptors, respectively). Displays cardioselectivity in vivo, over intestinal, tracheal and bladder muscarinic receptors; inhibits vagally and agonist-induced bradycardia.

Specifications

Chemical Identifiers

• CAS: 123548-16-3
• Molecular Formula: C27H37N5O2
• Molecular Weight (g/mol): 463.626
• InChI Key: BCUGCHZRMKTPMU-UHFFFAOYSA-N
• Synonym: aq-ra 741, aq-ra-741, 11-4-4-diethylamino butyl-1-piperidinyl acetyl-5,11-dihydro-6h-pyrido 2,3-b 1,4 benzodiazepin-6-one, 6h-pyrido 2,3-b 1,4 benzodiazepin-6-one,11-2-4-4-diethylamino butyl-1-piperidinyl acetyl-5,11-dihydro, acmc-20ej93, d0vz3d, aq-ra-741bs, chembl43383, 11-2-4-4-diethylamino butyl piperidin-1-yl acetyl-5h-benzo e pyrido 3,2-b 1,4 diazepin-6 11h-one
• PubChem CID: 129989
• IUPAC Name: 11-[2-[4-[4-(diethylamino)butyl]piperidin-1-yl]acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one
• SMILES: CCN(CC)CCCCC1CCN(CC1)CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4

• Quantity: 50 mg
• Formula Weight: 463.62
• Percent Purity: >99%
• Chemical Name or Material: AQ-RA 741