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ARHGEF17 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA538768
This item is not returnable.
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Description
Rho GTPases, which are activated by specific guanine-nucleotide exchange factors (GEFs), play pivotal roles in several cellular functions. TEM4, encoding a protein containing 1510 amino acids, contains a RhoGEF-specific Dbl homology (DH) domain but lacks their typical pleckstrin homology domain. TEM4 is a Rho-specific GEF with novel structural and regulatory properties and predomit expression in the heart. It couples tyrosine kinase signals with the activation of the rho/rac GTPases, thus leading to cell differentiation and/or proliferation. Elevated levels of TEM4, TEM5, TEM6, TEM7 and TEM7R were also raised in breast cancer tissues. TEM4 could also prove to be useful targets therapeutically.Specifications
ARHGEF17 | |
Polyclonal | |
Unconjugated | |
ARHGEF17 | |
P164RHOGEF, TEM4, p164-RhoGEF, 164 kDa Rho-specific guanine-nucleotide exchange factor, Rho-specific guanine-nucleotide exchange factor 164 kDa, rho guanine nucleotide exchange factor 17, tumor endothelial marker 4 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
207212, 9828 | |
-20°C | |
Liquid |
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin) | |
1 mg/mL | |
Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4 | |
Q96PE2, Q80U35 | |
ARHGEF17 | |
A synthetic peptide derived from the internal region of human ARHGEF17 | |
100 μg | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |