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Tocris Bioscience™ ARRY 520 trifluoroacetate
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Product Code. 30001682
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Quantity:
10 mg
Unit Size:
10mg
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Product Code. 30001682

Brand: Tocris Bioscience™ 4676/10

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This item is not returnable. View return policy

Description

Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation

Potent kinesin spindle protein (KSP) inhibitor (IC50 = 6 nM); selective for KSP over >250 other receptors and kinases at a concentration of 10 μM. Displays robust antitumor activity in bortezomib-resistant xenografts either alone or in combination with bortezomib. Induces degradation of Mcl-1; exhibits comparable cytotoxic activity to taxol (Cat. No. 1097) in epithelial ovarian cancer cells. Active in vivo.
TRUSTED_SUSTAINABILITY

Specifications

CAS 885060-09-3
Quantity 10 mg
Molecular Formula C20H22F2N4O2S
Formula Weight 420.48
Purity >98%
Molecular Weight (g/mol) 420.479
Chemical Name or Material ARRY 520 trifluoroacetate
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