AX 15836, > 98%, Tocris Bioscience™

Description

Potent and selective ERK5 inhibitor

Potent and selective ERK5 inhibitor (IC50 = 8 nM). Exhibits >1,000-fold selectivity for ERK5 over a panel of over 200 kinases. Also exhibits selectivity over bromodomain BRD4 (Kd = 3,600 nM). Increases vomocytosis in human macrophages in vitro, as well as in an in vivo zebrafish model of cryptococcal disease, reducing spread of infection.

Specifications

• CAS: 2035509-96-5
• Molecular Formula: C32H40N8O5S
• Linear Formula: C₃₂H₄0N₈O₅S
• Quantity: 10 mg
• Synonym: 5,11-dihydro-2-2-ethoxy-4-4-4-methyl-1-piperazinyl-1-piperidinyl carbonyl phenyl amino-5-methyl,11-methylsulfonyl-6h-pyrimido 4,5-b 1,4 benzodiazepin-6-one
• Solubility Information: Soluble to 100mM in 1eq. HCl and to 100mM in DMSO
• InChI Key: HTFNVAVTYILUCF-UHFFFAOYSA-N
• Molecular Weight (g/mol): 648.78
• PubChem CID: 122705989
• Formula Weight: 648.78
• Chemical Name or Material: 5,11-Dihydro-2-[[2-ethoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5-meth
• Grade: >98%