Axl Monoclonal Antibody (7E10), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA515504

Product Code. 11385473

Description

MA5-15504 targets AXL in indirect ELISA, IF and WB applications and shows reactivity with Human samples. The MA5-15504 immunogen is purified recombinant extracellular fragment of human AXL fused with hIgGFc tag expressed in HEK293 cell line. MA5-15504 detects AXL which has a predicted molecular weight of approximately 97.4kDa.

AXL is a chronic myelogenous leukemia-associated oncogene that is also associated with colon cancer and melanoma. The AXL protein is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6, and is involved in the stimulation of cell proliferation. TAM receptors are also involved in phagocytosis of apoptotic cells. Mice lacking all three TAM receptors have several degenerative phenotypes linked to inefficient removal of apoptotic cells and membranes (e.g., in the retina and the male reproductive tract) and develop a severe autoimmune phenotype akin to systemic lupus erythematosus, including the production of broad spectrum auto-antibodies. In addition, Axl may function as a putative entry receptor for filoviruses. Axl is also used to identify a specific subpopulation of human blood dendritic cells, also referred to as Siglec 6+/Axl+ dendritic cells. Cellular expression of Axl can be upregulated by TLR ligands, such as LPS or poly I:C. Soluble Axl is generated by proteolytic cleavage of the membrane form. Increased plasma levels may be indicative of inflammation and cancer.

Specifications

• Antigen: Axl
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: ascites with 0.03% sodium azide
• Gene Accession No.: P30530
• Gene Symbols: AXL
• Immunogen: Purified recombinant extracellular fragment of human AXL fused with hIgGFc tag expressed in HEK293 cell line.
• Regulatory Status: RUO
• Gene ID (Entrez): 558
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Immunocytochemistry, Western Blot
• Clone: 7E10
• Conjugate: Unconjugated
• Gene: AXL
• Gene Alias: Adhesion-related kinase; AI323647; ARK; AXL; AXL oncogene; AXL receptor tyrosine kinase; AXL transforming sequence/gene; AZF1; JTK11; oncogene AXL; sAXL; soluble AXL; Tyro7; Tyrosine-protein kinase receptor UFO; Ufo; ufo oncogene homolog
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1