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  5. 18735766

Tocris Bioscience™ AZD 5248

Potent cathepsin C inhibitor

Brand:  Tocris Bioscience™ 7130/1

Product Code. 18735766

  • £158.00 / 1mg

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Description

Description

AZD 5248 is a potent cathepsin C (also known as dipeptidyl peptidase 1, or DPP1) inhibitor (IC50 values are 44 and 67 nM for human and rat, respectively). In vivo, AZD 5248 inhibition of cathepsin C correlates to the reduction of NSP (neutrophil serine protease) activity measured in rat bone marrow and blood. In rats, quantitative whole-body autoradiography studies demonstrate aortic binding of AZ 5248. This compound is orally bioavailable.
Specifications

Specifications

4-Amino-N-[(1S)-1-cyano-2-(4'-cyano[1,1'-biphenyl]-4-yl)ethyl]tetrahydro-2H-pyran-4-carboxamide
1 mg
C22H22N4O2
1254318-44-9
Synthetic Cathepsin Inhibitors
0.98
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