Tocris Bioscience™ AZD 7648

Potent and selective DNA-PK inhibitor

Brand:  Tocris Bioscience™ 7825/50

Product Code. 18799076

Description

AZD 7648 is a potent (IC50 = 0.6 nM in an enzyme assay) and selective DNA-PK inhibitor. It is selective for DNA-PK over a range of kinases including PI3Kα, PI3Kδ, PI3Kγ, ATM, ATR and mTOR. In combination with radiotherapy, it leads to tumor regression in fully immuno-competent mice models. It also enhances the activity of PARP inhibitor Olaparib (Cat. No. 7579). AZD 7648 is orally bioavailable.

Specifications

• Chemical Name or Material: 7,9-Dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-8H-purin-8-one
• Quantity: 50 mg
• Molecular Formula: C₁₈H₂₀N₈O₂

• CAS: 2230820-11-6
• Target: DNA-dependent Protein Kinase Inhibitors