Tocris Bioscience™ BAY 876

Potent and selective GLUT1 inhibitor

Brand:  Tocris Bioscience™ 6199/5

Product Code. 18749246

Description

BAY 876 is a potent and selective GLUT1 inhibitor (IC50 = 2 nM) that displays selectivity for GLUT1 over GLUT2/3/4 (IC50 values are 10.8, 1.67 and 0.29 μM, respectively). BAY 876 induces cell death in hypoxic conditions in vitro and inhibits glucose uptake by Hela-MaTu cells. In ovarian cancer, BAY 876 reduces glycolysis rates and ATP production and inhibits proliferation in vitro and in vivo. This compound is cell permeable and orally bioavailable.

Specifications

• Chemical Name or Material: N4-[1-[(4-Cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-quinolinedicarboxamide
• Quantity: 5 mg
• Purity: 98%

• CAS: 1799753-84-6
• Molecular Formula: C₂₄H₁₆F₄N₆O₂