Benzyl chloroformate, 95%, stab. with ca 0.1% sodium carbonate, Thermo Scientific Chemicals

Description

Benzyl chloroformate is widely used as a reactive chemical intermediate in plastic, pharmaceutical, agricultural and organic chemicals. It is useful for the introduction of carboxybenzyl (cbz) protecting group for amines such as aniline in organic synthesis. It is also involved in the synthesis of 1,2,4-oxadiazoles.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Benzyl chloroformate is widely used as a reactive chemical intermediate in plastic, pharmaceutical, agricultural and organic chemicals. It is useful for the introduction of carboxybenzyl (cbz) protecting group for amines such as aniline in organic synthesis. It is also involved in the synthesis of 1,2,4-oxadiazoles.

Solubility
Miscible with ether, acetone and benzene.

Notes
Store in cool place. Moisture sensitive.

Specifications

Chemical Identifiers

• CAS: 501-53-1
• Molecular Formula: C8H7ClO2
• Molecular Weight (g/mol): 170.592
• MDL Number: MFCD00000640
• InChI Key: HSDAJNMJOMSNEV-UHFFFAOYSA-N
• Synonym: benzyl chloroformate, carbobenzoxy chloride, benzyl chlorocarbonate, cbz chloride, benzyloxycarbonyl chloride, carbobenzyloxy chloride, carbonochloridic acid, phenylmethyl ester, benzylcarbonyl chloride, cbz-cl, chloroformic acid, benzyl ester
• PubChem CID: 10387
• IUPAC Name: benzyl carbonochloridate
• SMILES: C1=CC=C(C=C1)COC(=O)Cl

• Melting Point: -20°C
• Density: 1.195
• Boiling Point: 178°C to 180°C
• Flash Point: 125°C (257°F)
• Odor: Acrid
• Refractive Index: 1.517
• Quantity: 250 g
• UN Number: UN1739
• Sensitivity: Moisture sensitive
• Merck Index: 14,1801
• Solubility Information: Miscible with ether,acetone and benzene.
• Formula Weight: 170.6
• Percent Purity: 95%
• Chemical Name or Material: Benzyl chloroformate, stabilized with ≈0.1% sodium carbonate

Safety and Handling

Product Identifier

• Benzyl chloroformate

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 4
• LONG-TERM AQUATIC HAZARD Chronic 1
• ACUTE AQUATIC Acute 1
• Carcinogenicity Category 1B
• Serious eye damage/eye irritation Category 1
• Substances and mixtures corrosive to metals Category 1
• Skin corrosion/irritation Category 1 B
• Skin sensitiser Category 1
• Specific target organ toxicity Category 3

Hazard Statement

• H290-May be corrosive to metals.
• H314-Causes severe skin burns and eye damage.
• H317-May cause an allergic skin reaction.
• H318-Causes serious eye damage.
• H332-Harmful if inhaled.
• H335-May cause respiratory irritation.
• H350-May cause cancer.
• H400-Very toxic to aquatic life.
• H410-Very toxic to aquatic life with long lasting effects.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P303+P361+P353-IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P310-Immediately call a POISON CENTER/doctor/.

Supplemental information

• MIXTURE LIST-Contains : Benzyl chloroformate, Benzyl chloride

RUO – Research Use Only