Bleomycin sulfate, Thermo Scientific Chemicals

Description

Bleomycin sulfate, CAS # 9041-93-4, is a glycopeptide compound with antibiotic activity isolated from Streptomyces verticillus. It also exhibits anticancer activity.

Bleomycin sulfate is used as a glycopeptide antibiotic. It is capable of inducing oxidative cleavage of the DNA backbone, leading to apoptosis and also degrades RNA, and has been reported to display selectivity for RNA over DNA. Bleomycin acts as a sclerosing agent.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Bleomycin sulfate was initially isolated from Streptomyces verticillus. It is a glycopeptide compound with antibiotic activity
• It has the ability to induce oxidative cleavage of the DNA backbone, leading to apoptosis
• Bleomycin sulfate can form a complex with iron that reduces oxygen to superoxide and hydroxyl radicals. These reactive oxygen species can cause single- and double-stranded breaks in DNA as well as promote carbohydrate oxidation, lipid peroxidation, and alterations in prostaglandin synthesis and degradation

Application

• It can be used to inhibit DNA metabolism and slow or stop cell growth. This property explains its anticancer activity
• Bleomycin sulfate can also be used to degrade RNA as it is more selective to RNA than DNA
• Local injections of bleomycin sulfate in mouse models can induce sclerotic skin mimicking scleroderma
• In laboratory research, bleomycin is used to induce pulmonary fibrosis in mice

Specifications

Chemical Identifiers

• CAS: 9041-93-4
• Molecular Formula: C55H85N17O25S4
• Molecular Weight (g/mol): 1512.619
• MDL Number: MFCD00070310
• InChI Key: WUIABRMSWOKTOF-UHFFFAOYSA-N
• PubChem CID: 131664136
• IUPAC Name: [2-[2-[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[[5-[[1-[2-[4-[4-(3-dimethylsulfoniopropylcarbamoyl)-1,3-thiazol-2-yl]-1,3-thiazol-2-yl]ethylamino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hyd
• SMILES: CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=N)[O-])O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O.OS(=O)(=O)O

• Type: Bleomycin Sulfate
• Physical Form: Powder
• Merck Index: 14,1318
• Solubility Information: Soluble in water or DMSO
• Color: White
• Quantity: 10 mg
• Chemical Name or Material: Bleomycin sulfate

Safety and Handling

Product Identifier

• Bleomycin sulfate

Signal Word

• Danger

Hazard Category

• Carcinogenicity Category 2
• Germ cell mutagenicity Category 1B
• Reproductive toxicity Category 2

Hazard Statement

• H340-May cause genetic defects.
• H351-Suspected of causing cancer.
• H361d-Suspected of damaging the unborn child.

Precautionary Statement

• P201-Obtain special instructions before use.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P308+P313-IF exposed or concerned: Get medical advice/attention.

Supplemental information

• MIXTURE LIST-Contains : Bleomycin, sulfate (salt)

RUO – Research Use Only