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Eurofins DiscoverX Blk Protein, Active
Active, recombinant full-length mouse Blk, containing an N-terminal His6-tag, for use in Kinase Assays.
Brand: Eurofins DiscoverX 14-316
Description
Activation of B cells by various ligands is accompanied by activation of src-family protein tyrosine kinases. Cross-linking of the B-cell receptor leads to the activation of src-family PTKs BLK (B-cell lymphocyte kinase), Fyn, and Lyn. Specific B and T cell progenitor subsets are preferentially susceptible to transformation by BLK and suggest a role for BLK in the control of proliferation during B cell development. BLK protein tyrosine kinase is found primarily in hematopoietic cells and inhibitors may be of therapeutic use in the treatment of B cell lymphoma.
GenBank M30903. The recombinant protein contains one residue which is in conflict with M30903. This is V421Eand is reported in ESTs BF731187 and BG145526.
Specifications
mg/mL of 50 mM Tris/HCl pH 7.5, 0.1 mM EGTA, 150 mM NaCl, 1 mM benzamidine, 0.03% Brij-35, 0.2 mM PMSF, 0.1% 2-mercaptoethanol, 270 mM sucrose. Frozen solution. | |
10 μg | |
Recombinant | |
Recombinant enzyme expressed in Sf21 insect cells | |
≥67% |
57.7 kDa | |
Mouse | |
N-terminal 6His | |
Full-length | |
Blk (mouse), active |