BMS 193885, Tocris Bioscience™

Description

Potent, competitive NPY Y1 receptor antagonist

Potent, competitive neuropeptide (NPY) Y1 antagonist (Ki = 3.3 nM, IC50 = 5.9 nM) that displays > 47, > 100, > 160, > 160 and > 160-fold selectivity over σ1, α1, Y2, Y4 and Y5 receptors respectively. Reduces food intake and body weight via central Y1 inhibition and is brain penetrant.

Specifications

Chemical Identifiers

• CAS: 679839-66-8
• Molecular Formula: C36H48N4O9
• Molecular Weight (g/mol): 680.80
• MDL Number: MFCD16878998
• InChI Key: BYHJIPSVXAFCDI-UHFFFAOYNA-N
• Synonym: 1,4-dihydro-4-3-3-4-3-methoxyphenyl-1-piperidinyl propyl amino carbonyl amino phenyl-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3,5-dimethyl ester l-lactate
• PubChem CID: 56972234
• IUPAC Name: 2-hydroxypropanoic acid; 3,5-dimethyl 4-{3-[({3-[4-(3-methoxyphenyl)piperidin-1-yl]propyl}carbamoyl)amino]phenyl}-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• SMILES: CC(O)C(O)=O.COC(=O)C1=C(C)NC(C)=C(C1C1=CC(NC(=O)NCCCN2CCC(CC2)C2=CC(OC)=CC=C2)=CC=C1)C(=O)OC

• Quantity: 50 mg
• Formula Weight: 680.79
• Percent Purity: >99%
• Chemical Name or Material: BMS 193885