Invitrogen™ Bovine Activated Protein C Native Protein

Native Protein

Brand:  Invitrogen™ RP43097

Product Code. 11544131

Description

Activated Protein C (bovine) Native Protein, RP-43097, from Invitrogen.

Protein C is a vitamin K-dependent plasma glycoprotein that is cleaved to its activated form by the thrombin-thrombomodulin complex. Protein C in its activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Protein C is a vitamin K-dependent serine protease produced in the liver and made up of 2 polypeptide chains. The 62 kDa proenzyme is activated by thrombin bound to an endothelial surface receptor and the active enzyme cleaves factor Va and VIIIa and thus inhibits blood coagulation. The molecular weight of the active enzyme is 55 kDa and the normal concentrations in human plasma is approximately 1-3ng/mL because of the very fast turnover, the proenzyme concentration is approximately 3ug/mL. Mutations in the Protein C gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis. RP-43097 contains native bovine Activated Protein C protein. RP-43097 may be used as a positive control in many immunological assays. The RP-43097 protein molecular weight is ∽52.65 kDa.

Specifications

• Accession Number: P00745
• Formulation: 50%water with 50% glycerol and no preservative
• Name: Bovine Activated Protein C
• Source: Bovine
• Regulatory Status: RUO
• Gene Symbol: PROC
• Conjugate: Unconjugated
• Species: Bovine
• Form: Liquid
• Purity or Quality Grade: purified

• For Use With (Application): Control
• Molecular Weight (g/mol): ∽52.65
• Quantity: 50μg
• Storage Requirements: -20°C, Avoid Freeze/Thaw Cycles
• Common Name: Bovine Activated Protein C
• Specific Reactivity: Bovine
• Cross Reactivity: Bv
• Recombinant: Native
• Protein Subtype: Native

in vitro research only.