BX 471, Tocris Bioscience™

Description

Potent, selective CCR1 antagonist

Potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1). Exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. Inhibits MIP-α/CCL3-induced intracellular Ca2+ mobilization. Orally active; effectively reduces disease severity in a rat model of multiple sclerosis. Decreases renal fibrosis in a mouse model of obstructive nephropathy.

Specifications

Chemical Identifiers

• CAS: 217645-70-0
• Molecular Formula: C21H24ClFN4O3
• Molecular Weight (g/mol): 434.896
• InChI Key: XQYASZNUFDVMFH-CQSZACIVSA-N
• Synonym: ZK-811752, unii-76k17zg4zn, r-1-5-chloro-2-2-4-4-fluorobenzyl-2-methylpiperazin-1-yl-2-oxoethoxy phenyl urea, 5-chloro-2-2-2r-4-4-fluorophenyl methyl-2-methylpiperazin-1-yl-2-oxoethoxy phenyl urea, n-5-chloro-2-2-2r-4-4-fluorophenyl methyl-2-methyl-1-piperazinyl-2-oxoethoxy phenyl-urea, urea, n-5-chloro-2-2-2r-4-4-fluorophenyl methyl-2-methyl-1-piperazinyl-2-oxoethoxy phenyl, bx-471free base, d05xzf, gtpl767
• PubChem CID: 512282
• IUPAC Name: [5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]phenyl]urea
• SMILES: CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC(=O)N)CC3=CC=C(C=C3)F

• Quantity: 10 mg
• Formula Weight: 434.89
• Percent Purity: >98%
• Chemical Name or Material: BX 471